Aspirin, a low water soluble compound with poor bioavailability, was complexed with fulvic acid to investigate dissolution and permeation properties. The release profile (dissolution rate) of aspirin increased from 31.32% in 30 minutes without FA, to 99.7% in 25 minutes when complexed with FA. The permeation of the FA-Aspirin complex across an everted rat gut sac was 8 times greater than compared to aspirin alone. As such, FA was concluded to be beneficial in enhancing the bioavailability of aspirin.
- Anwer, MK, Jamil, S, Ahmad, M, Ansari, MN and Khan, TH, 2013, Inclusion complex of solid state aspirin with fulvic acid: dissolution, permeability, stability and preliminary pharmacological studies, Journal of Biological Sciences, 13, 5, 302-312
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